Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 332043 - 378955:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_1G01010: pk
PKS_AT (530..831): pk
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 66.7%
2-Methylbutyryl-CoA: 62.5%
Methylmalonyl-CoA: 62.5%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 66.9
Methoxymalonyl-CoA: 58.5
Malonyl-CoA: 41.8
Ethylmalonyl-CoA: 37.5
Isobutyryl-CoA: 36.1
Propionyl-CoA: 28.3
Benzoyl-CoA: 23.0
trans-1,2-CPDA: 22.8
CHC-CoA: 17.3
fatty_acid: 14.1
2-Methylbutyryl-CoA: 12.1
3-Methylbutyryl-CoA: 10.8
inactive: 0.0
Acetyl-CoA: 0.0
CM000169.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 2655698 - 2714887:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:
Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DAMFAGGIFK
Nearest Stachelhaus code(s):
Val DAMFVGGVFK (85% 8Å match)
Stachelhaus code match:
80% (moderate)
CM000169.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
CM000169.1 - Region 4 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000169.1 - Region 5 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 4668799 - 4723141:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 4882296 - 4918979:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_1G17740: pk
PKS_AT (552..809): pk
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 62.5%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 64.1
Methoxymalonyl-CoA: 51.9
Ethylmalonyl-CoA: 44.8
Benzoyl-CoA: 34.4
Malonyl-CoA: 27.9
fatty_acid: 20.9
Isobutyryl-CoA: 19.3
trans-1,2-CPDA: 18.1
Propionyl-CoA: 15.6
CHC-CoA: 13.5
2-Methylbutyryl-CoA: 11.4
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
CM000170.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 286144 - 334706:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_2G01290: pk
PKS_AT (585..911): pk
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 83.3%
Methylmalonyl-CoA: 66.7%
Ethylmalonyl-CoA: 58.3%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 77.5
Methoxymalonyl-CoA: 67.8
Malonyl-CoA: 61.8
Isobutyryl-CoA: 55.4
Ethylmalonyl-CoA: 46.1
inactive: 26.4
fatty_acid: 22.1
Benzoyl-CoA: 22.0
Propionyl-CoA: 15.6
CHC-CoA: 10.5
trans-1,2-CPDA: 10.1
2-Methylbutyryl-CoA: 6.6
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
CM000170.1 - Region 2 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 4667843 - 4714505:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_2G17600: mal
PKS_AT (912..1212): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 100.0%
inactive: 62.5%
Isobutyryl-CoA: 54.2%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 118.2
inactive: 59.4
Methoxymalonyl-CoA: 46.4
Methylmalonyl-CoA: 38.5
Isobutyryl-CoA: 20.5
Benzoyl-CoA: 16.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 12.5
Ethylmalonyl-CoA: 10.5
fatty_acid: 9.8
Acetyl-CoA: 9.7
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
CM000170.1 - Region 3 - indole
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000171.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 332855 - 380985:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_3G01410: pk
PKS_AT (590..927): pk
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 83.3%
Methylmalonyl-CoA: 66.7%
Ethylmalonyl-CoA: 62.5%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 79.4
Methoxymalonyl-CoA: 76.1
Malonyl-CoA: 69.5
Isobutyryl-CoA: 40.4
Benzoyl-CoA: 31.9
2-Methylbutyryl-CoA: 29.0
Propionyl-CoA: 28.7
trans-1,2-CPDA: 26.9
inactive: 20.8
3-Methylbutyryl-CoA: 17.4
fatty_acid: 14.0
CHC-CoA: 7.7
Acetyl-CoA: 0.0
Ethylmalonyl-CoA: -2.1
CM000171.1 - Region 2 - NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 626905 - 673701:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_3G02570: mal
PKS_AT (914..1214): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 66.7%
inactive: 58.3%
Propionyl-CoA: 54.2%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 70.3
Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 54.7
inactive: 48.7
Ethylmalonyl-CoA: 33.8
fatty_acid: 30.1
Benzoyl-CoA: 29.4
Propionyl-CoA: 28.2
Isobutyryl-CoA: 24.1
CHC-CoA: 24.1
2-Methylbutyryl-CoA: 23.3
Acetyl-CoA: 18.6
trans-1,2-CPDA: 15.4
3-Methylbutyryl-CoA: 11.7
AFUA_3G02670: X
AMP-binding (45..434): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 872437 - 934474:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DVDGGGGIGK
Nearest Stachelhaus code(s):
Z-ahmohOrn DVDGGGGIGK (100% 8Å match)
Stachelhaus code match:
100% (strong)
CM000171.1 - Region 4 - NRPS,indole
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS: cds(Condensation and (AMP-binding or A-OX)) indole: (indsynth or dmat or indole_PTase)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 3410193 - 3456923:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
isocyanide-nrp: (DIT1_PvcA and minimum(2, [AMP-binding, PP-binding, Transferase])) NRPS: cds(Condensation and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3585652 - 3643193:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
APTKIVLKGK
Nearest Stachelhaus code(s):
Stachelhaus code match:
0% (weak)
CM000171.1 - Region 6 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3877250 - 3924985:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_3G14700: pk
PKS_AT (580..884): pk
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 79.2%
Methylmalonyl-CoA: 66.7%
Methoxymalonyl-CoA: 58.3%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 83.2
Methoxymalonyl-CoA: 71.5
Malonyl-CoA: 53.9
Propionyl-CoA: 53.7
Isobutyryl-CoA: 51.0
Ethylmalonyl-CoA: 50.4
trans-1,2-CPDA: 37.4
3-Methylbutyryl-CoA: 23.7
fatty_acid: 22.8
CHC-CoA: 20.3
2-Methylbutyryl-CoA: 19.2
Benzoyl-CoA: 18.6
inactive: 10.7
Acetyl-CoA: 0.0
CM000171.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 3990521 - 4037637:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DGYNAGSICK
Nearest Stachelhaus code(s):
Dhpg DAYNAGSLCK (50% 8Å match)
Stachelhaus code match:
80% (moderate)
CM000172.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 35987 - 81485:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_4G00210: mal
PKS_AT (921..1220): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 70.8%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 95.0
inactive: 59.5
Methoxymalonyl-CoA: 38.5
Methylmalonyl-CoA: 36.6
Isobutyryl-CoA: 13.5
2-Methylbutyryl-CoA: 9.8
Benzoyl-CoA: 7.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
CM000172.1 - Region 2 - isocyanide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000172.1 - Region 3 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 2914762 - 2959218:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DPRHFVMRAK
Nearest Stachelhaus code(s):
Aad DPRHFVMRAK (100% 8Å match)
Stachelhaus code match:
100% (strong)
CM000172.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole
12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000172.1 - Region 5 - fungal-RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000172.1 - Region 6 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3816930 - 3862461:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_4G14560: mal
PKS_AT (947..1245): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 75.0%
inactive: 62.5%
Methylmalonyl-CoA: 54.2%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 96.1
inactive: 61.9
Methylmalonyl-CoA: 52.5
Methoxymalonyl-CoA: 48.4
Propionyl-CoA: 41.6
CHC-CoA: 27.5
fatty_acid: 26.5
Benzoyl-CoA: 23.2
2-Methylbutyryl-CoA: 21.3
Isobutyryl-CoA: 20.6
Ethylmalonyl-CoA: 18.5
Acetyl-CoA: 14.6
trans-1,2-CPDA: 14.3
3-Methylbutyryl-CoA: 6.5
CM000173.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
CM000173.1 - Region 2 - isocyanide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000173.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000173.1 - Region 4 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2583085 - 2626910:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_5G10120: X
AMP-binding (13..414): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
gamexpeptide A, gamexpeptide B, gamexpeptide E, luminmide B, luminmide D, luminmide E, luminmide F, luminmide G
Photorhabdus laumondii subsp. laumondii
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 3294536 - 3360084:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:
pro (Pro)
Single AA prediction:
pro (Pro)
Stachelhaus prediction details:
Stachelhaus sequence:
DVLIAAAILK
Nearest Stachelhaus code(s):
Ala DVFIYAAILK (59% 8Å match)
Stachelhaus code match:
80% (moderate)
CM000174.1 - Region 1 - fungal-RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
CM000174.1 - Region 2 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 728394 - 773511:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_6G03480: X
AMP-binding (130..527): X
nrpys: (unknown)
SVM prediction details:
Predicted physicochemical class:
N/A
Large clusters prediction:
N/A
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DITLIGGPCK
Nearest Stachelhaus code(s):
Pro DITLVAGLIK (44% 8Å match)
Leu DAMLIGAICK (41% 8Å match)
Leu or Phe DAWTIGGVCK (38% 8Å match)
Stachelhaus code match:
60% (weak)
CM000174.1 - Region 3 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 2003278 - 2046507:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
-HSYMGHQLK
Nearest Stachelhaus code(s):
Stachelhaus code match:
0% (weak)
CM000174.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2319537 - 2379124:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 2993592 - 3055305:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:
Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:
ala (Ala)
Stachelhaus prediction details:
Stachelhaus sequence:
DIVMSAGALK
Nearest Stachelhaus code(s):
Ala DIVMSAGALK (100% 8Å match)
Stachelhaus code match:
100% (strong)
CM000174.1 - Region 6 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3531103 - 3578495:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_6G13920: X
AMP-binding (32..448): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) indole: (indsynth or dmat or indole_PTase)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 16016 - 61589:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_7G00160: mal
PKS_AT (927..1228): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 79.2%
inactive: 62.5%
Methylmalonyl-CoA: 54.2%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 94.2
Methylmalonyl-CoA: 61.7
Methoxymalonyl-CoA: 53.6
inactive: 53.1
Propionyl-CoA: 37.1
Ethylmalonyl-CoA: 24.1
Isobutyryl-CoA: 20.7
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 18.8
CHC-CoA: 18.0
3-Methylbutyryl-CoA: 13.6
fatty_acid: 12.6
Acetyl-CoA: 10.5
trans-1,2-CPDA: 9.2
CM000175.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000175.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
CM000176.1 - Region 1 - NRPS,indole
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS: cds(Condensation and (AMP-binding or A-OX)) indole: (indsynth or dmat or indole_PTase)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 853 - 53530:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_8G00170: X - X
AMP-binding (54..457): X
nrpys: Trp, Pro
SVM prediction details:
Predicted physicochemical class:
N/A
Large clusters prediction:
N/A
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DVMFIGAVNK
Nearest Stachelhaus code(s):
Trp or Pro DVMFIGAVNK (100% 8Å match)
Stachelhaus code match:
100% (strong)
AMP-binding (1148..1548): X
nrpys: Trp, Pro
SVM prediction details:
Predicted physicochemical class:
N/A
Large clusters prediction:
N/A
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DVYFVGGICK
Nearest Stachelhaus code(s):
Trp or Pro DVYFVGGICK (100% 8Å match)
Trp DVYFVGGICK (94% 8Å match)
Stachelhaus code match:
100% (strong)
CM000176.1 - Region 2 - NRPS,T1PKS,indole
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) NRPS: cds(Condensation and (AMP-binding or A-OX)) indole: (indsynth or dmat or indole_PTase)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 59284 - 159248:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:
N/A
Single AA prediction:
phe (Phe)
Stachelhaus prediction details:
Stachelhaus sequence:
DAYTMAAICK
Nearest Stachelhaus code(s):
Phe DAYTMAAICK (100% 8Å match)
Stachelhaus code match:
100% (strong)
CM000176.1 - Region 3 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 410402 - 453447:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
cluster extent as predicted by CASSIS
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 611459 - 657026:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
AFUA_8G02350: mal
PKS_AT (902..1175): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 58.3%
minowa: inactive
Prediction, score:
inactive: 56.8
Malonyl-CoA: 51.6
Methoxymalonyl-CoA: 32.3
Methylmalonyl-CoA: 18.3
Acetyl-CoA: 17.9
Propionyl-CoA: 17.0
Benzoyl-CoA: 14.0
Isobutyryl-CoA: 12.9
3-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
CM000176.1 - Region 5 - fungal-RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
MIBiG comparison
ClusterBlast
KnownClusterBlast
SubClusterBlast
Pfam domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows areas that are similar to the current region to a reference database. Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
reset view
zoom to selection