LOCUS       CM000173               18612 bp    DNA     linear   CON 23-MAR-2015
DEFINITION  Aspergillus fumigatus Af293 chromosome 5, whole genome shotgun
            sequence.
ACCESSION   CM000173
VERSION     CM000173.1
KEYWORDS    .
SOURCE      Aspergillus fumigatus Af293
  ORGANISM  Aspergillus fumigatus Af293
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Fumigati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2023-11-23 15:43:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: >18612
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     region          1..>18612
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     repeat_region   complement(1..105)
                     /rpt_type=tandem
                     /rpt_unit_seq="ttaggg"
                     /satellite="microsatellite"
     protocluster    1..15290
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[3151:5290]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3152..5290
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..15290
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     CDS             complement(join(1773..2093,2195..2492,2599..2846))
                     /codon_start=1
                     /locus_tag="AFUA_5G00100"
                     /note="encoded by transcript AFUA_5G00100A"
                     /old_locus_tag="Afu5g00100"
                     /product="integral membrane protein"
                     /protein_id="EAL86292.2"
                     /transl_table=1
                     /translation="MTSGLLIAQLALYAPLTLPTLYLLYRHGHHGLLAWLYLLAFCVLR
                     VTGAAMGLNDPHNAGSRIISSIGLSPLLLSIDGVLHEARIYCLSPSKRTEWTFMALIHV
                     LVATGVAMVGVGAGGLLGDTPKPSDLSNIKVGMVLLEVSWGVLALWGLWTLWNGTGGGR
                     KSARNQGAQAGLAAREGWLLLTGNLLALALVEISVVYMLVAEFTQRADLNPTTGSLAVR
                     VVLGFCPELLAAIVLVFAGFVTRGAGEVGAGEAGLGYGQGRRHRHAHGHGRRSSPKHGT
                     RSLSRSH"
     subregion       <1773..>18612
                     /aStool="cassis"
                     /abundance=4
                     /abundance_left=2
                     /abundance_right=2
                     /contig_edge="False"
                     /gene_left="AFUA_5G00100"
                     /gene_right="AFUA_5G00150"
                     /genes=7
                     /label="AFUA_5G00110"
                     /motif_left="+02_-01"
                     /motif_right="+02_-01"
                     /motif_score="3.0e+03"
                     /motif_score_left="1.5e+03"
                     /motif_score_right="1.5e+03"
                     /note="best prediction (most abundant) for anchor gene
                     AFUA_5G00110"
                     /promoter_left="AFUA_5G00100"
                     /promoter_right="AFUA_5G00145+AFUA_5G00150"
                     /promoters=5
                     /subregion_number="1"
     gene            complement(<1773..>2846)
                     /locus_tag="AFUA_5G00100"
                     /old_locus_tag="Afu5g00100"
     mRNA            complement(join(<1773..2093,2195..2492,2599..>2846))
                     /locus_tag="AFUA_5G00100"
                     /note="transcript AFUA_5G00100A"
                     /old_locus_tag="Afu5g00100"
                     /product="integral membrane protein"
     promoter        2796..3150
                     /locus_tag="AFUA_5G00100"
                     /seq="GTTAGGGGGGCGTAGAGGGCGAGTTGCGCGATGAGGAGTCCGGATGTCATCTT
                     CACTCATTCAGTGTAGGAGATGGGTGATGTTGGTGCAGTGCAGGTTTAGGAGAGATACG
                     GGGAGATGGATTGGGGCAGAGTAAAAGGTAGACAAATAATCCATTTTAGGCAACCAGTT
                     CTAGGCCATATAGTTAAGATGCCAGCCAAGAGGCCCAAGGCGCAGGGCCGAGACGCTAC
                     TAAACGAGACCGAGAATCCTTGTCAGTCAGAGCCAATCCTCTGCGACGCCTCATGCAAG
                     GGTTCACGAACTAAATCCAAACAGGCAATCCAGACAAAAAGCTTGAACCAAACAAGACC
                     AGCAGAT"
                     /tool="antismash"
     gene            complement(<3152..>5290)
                     /locus_tag="AFUA_5G00110"
                     /old_locus_tag="Afu5g00110"
     mRNA            complement(join(<3152..4150,4274..>5290))
                     /locus_tag="AFUA_5G00110"
                     /note="transcript AFUA_5G00110A"
                     /old_locus_tag="Afu5g00110"
                     /product="squalene-hopene-cyclase, putative"
     CDS             complement(join(3152..4150,4274..5290))
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_5G00110"
                     /note="encoded by transcript AFUA_5G00110A; similar to
                     GB:BAC91998.1: squalene-hopene cyclase [Gloeobacter
                     violaceus PCC 7421]; GO_function: GO:0051007 -
                     squalene-hopene cyclase activity; GO_process: GO:0019746 -
                     hopanoid biosynthetic process"
                     /old_locus_tag="Afu5g00110"
                     /product="squalene-hopene-cyclase, putative"
                     /protein_id="EAL86291.2"
                     /sec_met_domain="terpene_cyclase (E-value: 3.2e-21,
                     bitscore: 72.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MATLTTTMATTATMATTEASKPLEAQARTALTKATNYAWEIFSNR
                     HWCGELESNVTVTCEHIFFLYVLYQHIDPGEGSQYRQWLLLQQNSDGSWGIAPNYPGDI
                     STSAEAYLALRIIGMSTDSPELYRARTFIRAAGGLSKMRMFTRIFFAEFGLVPWTAIPQ
                     LPAEFILVPAHFPISIYRLASWARSNVVPLLIIAHHRPLYPLPNGLHKQNPFLDELWLD
                     PATKPLPYGSSDPTDPVAFVFTILDKALSYLGGLRRSPTRGYARRRCVQWILQHQEKAG
                     DWAGIIPPMHAGIKALLLEGYKLHDEPIQLGLAAIERFTWADNRGKRLQCCISPVWDTR
                     VYKPNIPVGGWAFEYHNTWYPDIDDTAAAVLAFLTHDPATARSRLVRDAVLWIVGMQNA
                     DGGWAAFDHENNQLFLNKIPFSDMESLCDPSTPDVTGRTIECLGMLRDLLMRPAENAEN
                     GEKYGYPDGEGDAAADAHLLQIINTACARAIPYLIRSQEATGTWYGRWAVNYVYGTCLV
                     LCGLQYFKHDPKFAPEIQAMAARAVKWLKQVQNSDGGWGESLLSYREPWRAGCGPSTPS
                     QTAWALMGILTVCGGEDRSVQRGVRHLVDTQDDTLSQGDGGAAAWTEREFTSTGFPNHF
                     YISYTLYRVYFPITALGRYLSLIEGGQEKKKKGGGT"
     PFAM_domain     complement(3203..3721)
                     /aSDomain="SQHop_cyclase_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13243.9"
                     /description="Squalene-hopene cyclase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00110_0003"
                     /evalue="2.80E-56"
                     /label="AFUA_5G00110"
                     /locus_tag="AFUA_5G00110"
                     /protein_end="655"
                     /protein_start="482"
                     /score="191.0"
                     /tool="antismash"
                     /translation="TACARAIPYLIRSQEATGTWYGRWAVNYVYGTCLVLCGLQYFKHD
                     PKFAPEIQAMAARAVKWLKQVQNSDGGWGESLLSYREPWRAGCGPSTPSQTAWALMGIL
                     TVCGGEDRSVQRGVRHLVDTQDDTLSQGDGGAAAWTEREFTSTGFPNHFYISYTLYRVY
                     FPITALGRYL"
     PFAM_domain     complement(join(3827..4150,4274..4279))
                     /aSDomain="SQHop_cyclase_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13243.9"
                     /description="Squalene-hopene cyclase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00110_0002"
                     /evalue="1.30E-34"
                     /label="AFUA_5G00110"
                     /locus_tag="AFUA_5G00110"
                     /protein_end="447"
                     /protein_start="337"
                     /score="119.9"
                     /tool="antismash"
                     /translation="DTRVYKPNIPVGGWAFEYHNTWYPDIDDTAAAVLAFLTHDPATAR
                     SRLVRDAVLWIVGMQNADGGWAAFDHENNQLFLNKIPFSDMESLCDPSTPDVTGRTIEC
                     LGMLRD"
     PFAM_domain     complement(4319..5164)
                     /aSDomain="SQHop_cyclase_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13249.9"
                     /description="Squalene-hopene cyclase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00110_0001"
                     /evalue="5.50E-94"
                     /label="AFUA_5G00110"
                     /locus_tag="AFUA_5G00110"
                     /protein_end="324"
                     /protein_start="42"
                     /score="314.7"
                     /tool="antismash"
                     /translation="SNRHWCGELESNVTVTCEHIFFLYVLYQHIDPGEGSQYRQWLLLQ
                     QNSDGSWGIAPNYPGDISTSAEAYLALRIIGMSTDSPELYRARTFIRAAGGLSKMRMFT
                     RIFFAEFGLVPWTAIPQLPAEFILVPAHFPISIYRLASWARSNVVPLLIIAHHRPLYPL
                     PNGLHKQNPFLDELWLDPATKPLPYGSSDPTDPVAFVFTILDKALSYLGGLRRSPTRGY
                     ARRRCVQWILQHQEKAGDWAGIIPPMHAGIKALLLEGYKLHDEPIQLGLAAIERFTWAD
                     N"
     promoter        5240..5888
                     /locus_tag="AFUA_5G00110"
                     /locus_tag="AFUA_5G00120"
                     /note="bidirectional promoter"
                     /seq="GTAGTTGCCATGGTTGCCGTAGTGGCCATCGTAGTCGTCAAGGTTGCCATGGT
                     CAGTGATACCGAGCAAAAGAAGCAGGGTGATGAGCAGAGACCCTTAAGTACTCGATCAA
                     CCGTCCGTCTCGTTCCCCTCAGAACTAGACCGGTCTGGTTGTCATCGCCTGCGTAAGCG
                     TACCATCATTAGGGGCTAGCCTGTAAGTTTGGTTCTTCTCCATTCCAGGCCAGGGCCTA
                     ATCATTACAATTCTTCCAATACGAAGGGTTACATCAGGCTAATAGTGAGGGTGCTGAAT
                     CATCACCACATCAGCTTACGACTATGCAGTGCTATCTGGACATCTATTGGAGGCTCCCT
                     TATCGCACCCAACATCCGTAAATGACTCACGAGAAATGGAGCAGATTCAGCCGAAACCC
                     ATACCGCAGCTTGTCGGCTTTCCTCTGTTACCAAAAAGAAAGTACCATACAGATATCGA
                     CCCTAATCCGGACAGGGGAGAGGGCAGAAAGGCTATATAAACTTACAAACATCCACCTT
                     CACATCCACCACATCATTTACCCAATTTAACTCCTCCTGCCTAATTTCAACCCTGTATG
                     GAACAATTGCCATCATGTATACAGCCCTTGGCCTAGCCGTCTTCACCGCCCTTTTTCAC
                     TACACC"
                     /tool="antismash"
     gene            <5839..>7498
                     /locus_tag="AFUA_5G00120"
                     /old_locus_tag="Afu5g00120"
     mRNA            join(<5839..6946,7005..7271,7347..>7498)
                     /locus_tag="AFUA_5G00120"
                     /note="transcript AFUA_5G00120A"
                     /old_locus_tag="Afu5g00120"
                     /product="cytochrome P450 oxidoreductase/alkane
                     hydroxylase, putative"
     CDS             join(5839..6946,7005..7271,7347..7498)
                     /EC_number="1.14.14.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 265; E-value: 2.3e-80)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_5G00120"
                     /note="encoded by transcript AFUA_5G00120A; similar to
                     SP:Q9Y757: Cytochrome P450 52A12 ([Debaryomyces hansenii];
                     GO_function: GO:0016491 - oxidoreductase activity;
                     GO_process: GO:0008152 - metabolic process"
                     /old_locus_tag="Afu5g00120"
                     /product="cytochrome P450 oxidoreductase/alkane
                     hydroxylase, putative"
                     /protein_id="EAL86290.2"
                     /sec_met_domain="p450 (E-value: 3.9e-61, bitscore: 203.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MYTALGLAVFTALFHYTIVLAINHYRTREILSQLVKAHNCCPPKT
                     ERPWDILGLVKIYSSTKHLLNETALSNVSALFKCYGDTYASRILTQRVYFTCDPRNIRH
                     VLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWKEARSLYADIFSATRKIFDLQLQE
                     DGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTLKQDQSLEKKEVAEALMY
                     AKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEMTAREYQKQSNAATVDDE
                     RQKRTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHERVYAKLR
                     QEILDTIGTEPPTYDNIRKATYLRYVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQ
                     SGVLIRKGQRVIFASWGSHRSTRSFGADALEFRPERWEGLKSESLGYIPFSAGPRVCLG
                     QQYALLEASYATIRIIQTFERLENRDVRPWTEKIGLNLSNKNGVLVELVH"
     PFAM_domain     join(5965..6946,7005..7271,7347..7447)
                     /ASF="active site cysteine inconclusive"
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00067.25"
                     /db_xref="GO:0004497"
                     /db_xref="GO:0005506"
                     /db_xref="GO:0016705"
                     /db_xref="GO:0020037"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00120_0004"
                     /evalue="6.10E-60"
                     /gene_ontologies="GO:0004497: monooxygenase activity"
                     /gene_ontologies="GO:0005506: iron ion binding"
                     /gene_ontologies="GO:0016705: oxidoreductase activity,
                     acting on paired donors, with incorporation or reduction of
                     molecular oxygen"
                     /gene_ontologies="GO:0020037: heme binding"
                     /label="AFUA_5G00120"
                     /locus_tag="AFUA_5G00120"
                     /protein_end="492"
                     /protein_start="42"
                     /score="203.4"
                     /tool="antismash"
                     /translation="PKTERPWDILGLVKIYSSTKHLLNETALSNVSALFKCYGDTYASR
                     ILTQRVYFTCDPRNIRHVLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWKEARSLY
                     ADIFSATRKIFDLQLQEDGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTL
                     KQDQSLEKKEVAEALMYAKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEM
                     TAREYQKQSNAATVDDERQKRTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLS
                     TTFYLLARHERVYAKLRQEILDTIGTEPPTYDNIRKATYLRYVFNEAMRVYPPVPFNAR
                     TANRDTYLPAGGGPDGQSGVLIRKGQRVIFASWGSHRSTRSFGADALEFRPERWEGLKS
                     ESLGYIPFSAGPRVCLGQQYALLEASYATIRIIQTFERLENRDVRPWTEKI"
     promoter        7499..8094
                     /locus_tag="AFUA_5G00130"
                     /seq="GTCGTGGAATACAGGCATATGCGTGTCTGGCGAGACTGCAGGGGGCCGCTAGA
                     CGTAGTTAGGTAGCCAATCAGGGAGCACTCACATGAAGATGGCTTGAAGACTACTTAAT
                     ATGATTGGTAACACCCTTGTTCAAGCCTTGCCCAGTCTGCTCAAGCTTGCCCAAGCCTT
                     GACAGGGGCCAGAATCCTCCGCCAAAATCTCACCGGCGCCAACACGGACAACCCCTCTC
                     TTATATTATTTTGGTCCCTCAATATGTGATTATGCCGCATCATCACGACAAGGATGGCT
                     AGATGAGACGCCAGAGCTGGGAATTGGCCCCAAGACCGAGACCGAAACCGAGACCGAGT
                     ATCCCTGTCGCGCTGTAAGTATGGCATCATAGACAAGAGCTGGTCTAATTTCGATAGAG
                     ACAATCGGGAAGCAGACATATCTCCAACACTCCTGTAGGGCTATGTTGTATCGTAGAAT
                     GTAGTGGATATCAACTCTCTTGCGTCCACCCTGGGTGAATTCGAAATCACAATTGCTTC
                     TAAACCACACTGCAGACAAAATGGCCATCCCAACAAAAGAAAGGGGTAGCCGCCTCACT
                     GACGCCGATATT"
                     /tool="antismash"
     gene            <8045..>9220
                     /locus_tag="AFUA_5G00130"
                     /old_locus_tag="Afu5g00130"
     mRNA            <8045..>9220
                     /locus_tag="AFUA_5G00130"
                     /note="transcript AFUA_5G00130A"
                     /old_locus_tag="Afu5g00130"
                     /product="capsule polysaccharide biosynthesis protein,
                     putative"
     CDS             8045..9220
                     /codon_start=1
                     /locus_tag="AFUA_5G00130"
                     /note="encoded by transcript AFUA_5G00130A; similar to
                     GB:BAB72030.1: capsular polysaccharide [Photobacterium
                     damselae]; GO_process: GO:0045227 - capsule polysaccharide
                     biosynthetic process"
                     /old_locus_tag="Afu5g00130"
                     /product="capsule polysaccharide biosynthesis protein,
                     putative"
                     /protein_id="EAL86289.1"
                     /transl_table=1
                     /translation="MAIPTKERGSRLTDADILSDLQMYKPVTDSDTRNVWAFWDKGLSN
                     SPAWNQRNVISWVRRLSPKWTVRVLDLVEGSPNHVSQFIPREMLTDVFWNRTMTGPHVG
                     QHSSDLIRLPLLYLYGGVWLDVGMLLFRSLDALCWNALEDPETPYEVAAFKVSMGPELS
                     FLFNGFIAARRGSVCIKYWHEIFRTLWDGATSCAGMHSHPLLAHLPVYEPPSLNGKRPP
                     FMYAQFADYLAQVFCLERLRHLVDSKTGWDGPKFFEEKVLLFDCVTEAYWAQRLTDWNG
                     RKQYELLDLQRGEDGLDNARVKEAEALVQGVLSMSSTMKLSHGLVTAGREYLADIWDSP
                     KNHDADIRPGTFAAYLREASETFEQTKELVPLRMPVIEKALLRAGVTEVVR"
     PFAM_domain     8108..8614
                     /aSDomain="Caps_synth"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF05704.15"
                     /db_xref="GO:0016757"
                     /description="Capsular polysaccharide synthesis protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00130_0005"
                     /evalue="3.70E-11"
                     /gene_ontologies="GO:0016757: glycosyltransferase activity"
                     /label="AFUA_5G00130"
                     /locus_tag="AFUA_5G00130"
                     /protein_end="190"
                     /protein_start="21"
                     /score="43.1"
                     /tool="antismash"
                     /translation="QMYKPVTDSDTRNVWAFWDKGLSNSPAWNQRNVISWVRRLSPKWT
                     VRVLDLVEGSPNHVSQFIPREMLTDVFWNRTMTGPHVGQHSSDLIRLPLLYLYGGVWLD
                     VGMLLFRSLDALCWNALEDPETPYEVAAFKVSMGPELSFLFNGFIAARRGSVCIKYWHE
                     IFRTLW"
     gene            complement(<9314..>10498)
                     /locus_tag="AFUA_5G00135"
     mRNA            complement(join(<9314..9376,9396..10277,10322..>10498))
                     /locus_tag="AFUA_5G00135"
                     /note="transcript AFUA_5G00135A"
                     /product="C6 finger domain protein"
     CDS             complement(join(9314..9376,9396..10277,10322..10498))
                     /codon_start=1
                     /locus_tag="AFUA_5G00135"
                     /note="encoded by transcript AFUA_5G00135A"
                     /product="C6 finger domain protein"
                     /protein_id="EBA27266.1"
                     /transl_table=1
                     /translation="MLDRSKMTSAIPDSNSSSSPRGHNQSERDSYNRKKRKGPRLAHRK
                     SRTGCQRCRARRVKCDESRPVCRDCHRHGIPCVYDRPAEEGAIPPSTGIQSRPLEPSPS
                     DPSNDAHMELRLLHHFTLFTSATMPGAHLKRIKDCWSIDVPRLAFSYKPLLHAVFAIAA
                     LHLSKVNPDEAGLPDIHCNFLEQALREHRLCIGGITTQTADAVCFTSILLQIDVFATLQ
                     SRHVVSYEQVSEWMRLVRGSVAVFDAAMEIVRHNTHPPNIWCIIDTFPMPLRTSSDAGS
                     FSFLLPTVPDDEDDETALEAYRGAVAHINATWLAMEAKEHPQISCRRLMVFPLFVTAGF
                     IDLLEKRRPRALVPCPHHYVTYGGSETLHTNTS"
     PFAM_domain     complement(9729..10112)
                     /aSDomain="Fungal_trans_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF11951.11"
                     /description="Fungal specific transcription factor domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00135_0007"
                     /evalue="6.30E-06"
                     /label="AFUA_5G00135"
                     /locus_tag="AFUA_5G00135"
                     /protein_end="242"
                     /protein_start="114"
                     /score="25.4"
                     /tool="antismash"
                     /translation="RLLHHFTLFTSATMPGAHLKRIKDCWSIDVPRLAFSYKPLLHAVF
                     AIAALHLSKVNPDEAGLPDIHCNFLEQALREHRLCIGGITTQTADAVCFTSILLQIDVF
                     ATLQSRHVVSYEQVSEWMRLVRGS"
     PFAM_domain     complement(join(10206..10277,10322..10357))
                     /aSDomain="Zn_clus"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00172.21"
                     /db_xref="GO:0000981"
                     /db_xref="GO:0006355"
                     /db_xref="GO:0008270"
                     /description="Fungal Zn(2)-Cys(6) binuclear cluster domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00135_0006"
                     /evalue="2.20E-09"
                     /gene_ontologies="GO:0000981: DNA-binding transcription
                     factor activity, RNA polymerase II-specific"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /gene_ontologies="GO:0008270: zinc ion binding"
                     /label="AFUA_5G00135"
                     /locus_tag="AFUA_5G00135"
                     /protein_end="83"
                     /protein_start="47"
                     /score="37.4"
                     /tool="antismash"
                     /translation="TGCQRCRARRVKCDESRPVCRDCHRHGIPCVYDRPA"
     promoter        10448..11498
                     /locus_tag="AFUA_5G00135"
                     /seq="GACGAGTTACTGTCTGGGATGGCCGAGGTCATCTTGCTTCGGTCCAACATGTC
                     ATGGCGATGGAGTTCCAGCGCAGCGATGACATATCCTGGGGTCTTTCGGATTCGGTGAA
                     GAGGAGCGAAGCCTTCCTCAGTTTGTCTAGCGGGAACCACGATCGCCGAATGGTTGACC
                     TGTGGGTACTTGCCTCCAAAAATGGAAAGACGGGCCAGCAGAAGGTACTGGAAGTAGTA
                     GGTAAGTTACCTGAATATTAAACTCCTCTTAAAGTAGGCAATAATAAATAGTAGCACGT
                     CCCACCCAGATAGGTGTAGGCCGCCAGTTATTGAGTGTAACAAAAGTTCCTGATGGACG
                     GGGGCCGCCCTCACTAGCAACTCCCGGTCTTAATGTAATCAATCCACCGCCGAGCTGAC
                     CAACCACCCCCCTGCGAGCCGATCACCCCTCGTCTGATTTCTACGCGTTTGAACATTTG
                     AAGCCATCCAAATCAACTAAAATGATATACTTTTCATTAGATCTAGCTAGTGCAGTGTG
                     TAGCGCAGCTAGATCCAGTATGTCTAATAATGAAGTAATTAGAACCCCTTAGTGGCGTG
                     TATTTAGAAGGTTCTAAGGTAAACGCTTGGAACCACTAACTCACTGACCCCTAACGTAA
                     TTCCCAGACGAGCCGGACACTCCATCACATTTCAATGTTTTTACACCTTCGATGCTATC
                     AAAACAGCTACCATGCCACAAAAATCATGTCAAACCTCTCAAAATCTAGTATATCAAGA
                     GGGGAGGATCTTATTAGCAATATCATCTTTGAAAAAGCAGGAAATTCAAAGTATCACCA
                     TGCTGCAGAGATATTCAACGTGCCTAAGTCAACCCTCTACAATGACTTCATGGATGCCA
                     ATATTAATTGAAGAAATGCGCAAATAACTGTCGGCGATCTCCTACACAGGAAGAATTAT
                     TAGTAGAATGGATGCTATCTAGGTATCAGTGTGGAGCGCCCCTTTGCGCCATCTTATAT
                     ATAAGAAATAGCCAATATCCTTCTCCAGGCAGATGATCCCTCTGGATTCAAACC"
                     /tool="antismash"
     repeat_region   complement(11641..11667)
                     /rpt_type=tandem
                     /rpt_unit_seq="gcgtcgaatcca"
                     /satellite="microsatellite"
     repeat_region   complement(11674..11715)
                     /rpt_type=tandem
                     /rpt_unit_seq="tcagagccagta"
                     /satellite="microsatellite"
     mobile_element  complement(12613..13545)
                     /mobile_element_type="transposon:hAT transposon family"
     gene            complement(<15749..>16327)
                     /locus_tag="AFUA_5G00145"
     mRNA            complement(join(<15749..15940,15992..>16327))
                     /locus_tag="AFUA_5G00145"
                     /note="transcript AFUA_5G00145A"
                     /product="conserved hypothetical protein"
     CDS             complement(join(15749..15940,15992..16327))
                     /codon_start=1
                     /locus_tag="AFUA_5G00145"
                     /note="encoded by transcript AFUA_5G00145A; similar to 4MeS
                     (GI:2352900) [Metarhizium anisopliae]"
                     /product="conserved hypothetical protein"
                     /protein_id="EAL86288.2"
                     /transl_table=1
                     /translation="MLFSRVTPVALLVALATSALGEVNTKQAIEGMNTLQKRVSKARES
                     IEGWDGGLLGVIPIASKMQGVKSSTADTRRTIEQSDAFGDEDQDEVLAAYQQLQPEIVG
                     ALNAAEQKAPAFKDAGVAFVARAMMDDLKSEKEKFKTTMQEKVPAERYRSTEPKVAEVN
                     AAFDSAHKALSA"
     PFAM_domain     complement(join(15845..15940,15992..16249))
                     /aSDomain="HsbA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12296.11"
                     /description="Hydrophobic surface binding protein A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00145_0008"
                     /evalue="6.10E-23"
                     /label="AFUA_5G00145"
                     /locus_tag="AFUA_5G00145"
                     /protein_end="144"
                     /protein_start="26"
                     /score="81.7"
                     /tool="antismash"
                     /translation="QAIEGMNTLQKRVSKARESIEGWDGGLLGVIPIASKMQGVKSSTA
                     DTRRTIEQSDAFGDEDQDEVLAAYQQLQPEIVGALNAAEQKAPAFKDAGVAFVARAMMD
                     DLKSEKEKFKTTMQ"
     promoter        16277..17808
                     /locus_tag="AFUA_5G00145"
                     /locus_tag="AFUA_5G00150"
                     /note="bidirectional promoter"
                     /seq="GTCGCGAGGGCGACGAGCAGCGCTACTGGGGTCACGCGGGAGAAGAGCATTGT
                     GTCTTAGGAAAGAATGGGATTGGGTTGAAATAAAATCAAGAGTGTACTGTGATTGGGGA
                     TGTCTTAAAAGTTTGTTTCATGTCATGACTTTATAGCCGGGGCAGCGTCGCCAAGGTCC
                     ATTCCTATATATCACACTGGCCCAAGACAGGGAGGGGCAAATACCGTTGACCATACCCG
                     GAATGTGAGGGGCCGCCATCGCAGCAAATTCTCCGTTACGTGGTTTGAAGTATGAAAGA
                     CAGCAGGAGAAACAGGGGAGCACTGTTCGCCATTAAATATCCTGCAGTTGAGGCTAAAT
                     CCCCATGTATGCAGTGTAACTCTGATACTAGATTATGAGGCTATATCCTGAATATCCCT
                     TCTTGTATACAGTATAAACCCGACCTACCTGCCACATTCAAGCATCCATGCGCCGTAGA
                     TAGAATGCAAAGGGCGAATTTGGCATTCTCCGGGAAATAAAGGGGCTTCCTGATACTGG
                     CAAGACGTATGACTTAATGCTTGATGATGGCAGGTTTGACAATATACATATTTTTGACA
                     ACAGCGGATGTTGCCAGCTCAAGGAAGGACCCGTCCTTGCTCTGTGGCCGCAGCGTCAA
                     TCTCCAGGGAAAACATCCAAGATTCATCTTATAGCCGCTCTGTCATTATACACCCTTCT
                     TACTCTGGCTGCACCCGTCACGGTACAATTCTGATTGAGGATCTCGAATGTCTCTTCCC
                     ACGTAACGGTTTGTGTCTGGTCAGGCCGAACAAGATTGAAGGCGAGGCAGAGGTTTTCA
                     CTGAACAGAGAAATCCGCAGCATGGAGGAGCAGACAAAGCGAACTGCAATGAATTGGTG
                     TCGGGCATGTGGAGTAACAGGATAGCTGCAAATGCGATGACAGTTGGCTATCAGACGAT
                     TAGTAGCATGCTGCTGTTTATGGGCCCCAGTGACGCTCTGGCGCATGACGAATCCAGGC
                     GGATATACTGGAGACATAATTGTGCGGCTTAGGGCGTCCAGTGTACGCAAAGGCATAGC
                     TATTACTCCAATGATGCAAAAGCCAGGTATGAAACAATGACCGCCATATCACACCGAAT
                     CATGATGATCACAAACGTGCGACTGTACATACTTCCCCTGCATGCCACGGAACGAACGT
                     CGTTGGCGGAGCTCCCCCGTTCTACCTTGCAGCGCGGAGTTGCAAGTGGCCAATTATAT
                     GGAGGAGACTGAAAGTGACAACCTGATCTGAACGTACTCGCAACAAACTATATTCAAAC
                     CGCCTCAGTCACCAATTGAGCAAGCTATTTGTAGAGGAGCTGGCGGAACTCCTCTGCCT
                     ATCTCGAGATGATATTGAGATAGATACCGACCTTCTCGAATTGGGCCTGACGTCAGTGA
                     ACCTCATTCAACTTCACTATCGATTGCAGAGGAGACTGTTGCCTGATGAGATTATTCCT
                     CTTCCTACTATCATGGCGTACCACACCATACGAGGTTTAGCTGAGGCATGCCAGCAGCG
                     TCAC"
                     /tool="antismash"
     gene            <17759..>18612
                     /locus_tag="AFUA_5G00150"
                     /old_locus_tag="Afu5g00150"
     mRNA            join(<17759..18123,18141..>18612)
                     /locus_tag="AFUA_5G00150"
                     /note="transcript AFUA_5G00150A"
                     /old_locus_tag="Afu5g00150"
                     /product="thioesterase domain protein"
     CDS             join(17759..18123,18141..18612)
                     /NRPS_PKS="Domain: Thioesterase (32-119). E-value: 4.5e-18.
                     Score: 58.3. Matches aSDomain:
                     nrpspksdomains_AFUA_5G00150_Thioesterase.1"
                     /codon_start=1
                     /locus_tag="AFUA_5G00150"
                     /note="encoded by transcript AFUA_5G00150A; similar to BarG
                     (GI:23452298) [Lyngbya majuscula] PMID: 12383521 similar to
                     probable serine activating enzyme (Swiss-Prot:P45745)
                     [Bacillus subtilis] PMID: 8550523 PMID: 11112781;
                     GO_function: GO:0016788 - hydrolase activity, acting on
                     ester bonds; GO_process: GO:0009058 - biosynthetic process"
                     /old_locus_tag="Afu5g00150"
                     /product="thioesterase domain protein"
                     /protein_id="EAL86287.1"
                     /transl_table=1
                     /translation="MAYHTIRGLAEACQQRHQYIPAVALQPKGGKSPLWLVHAAAGEAL
                     IFINLARLINDQPVYAFKARGFVCGEIYFTSIDECVRTYYEAIKELQPHGPHAILEYSY
                     GGMLAFELAKIWRRKKISLNRPPYVSARLQEVKWTDCLVNISYFLGLLSRASFRDLLQQ
                     LYHLPKKEATACLIKVADPARLVALALDNDKPEQWIDVAPSPQEVGRNYTPQGSVAHMD
                     VFHCDPLEFLNVTPQEWQQRLSSWRDSQGRGSTSFTCQASTSLFWDRQTSKHSSTD"
     aSDomain        17855..18115
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_5G00150_Thioesterase.1"
                     /evalue="4.50E-18"
                     /label="AFUA_5G00150_Thioesterase.1"
                     /locus_tag="AFUA_5G00150"
                     /protein_end="119"
                     /protein_start="32"
                     /score="58.3"
                     /tool="antismash"
                     /translation="PLWLVHAAAGEALIFINLARLINDQPVYAFKARGFVCGEIYFTSI
                     DECVRTYYEAIKELQPHGPHAILEYSYGGMLAFELAKIWRRK"
     PFAM_domain     17855..18115
                     /aSDomain="Thioesterase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00975.23"
                     /db_xref="GO:0009058"
                     /description="Thioesterase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_AFUA_5G00150_0009"
                     /evalue="5.60E-14"
                     /gene_ontologies="GO:0009058: biosynthetic process"
                     /label="AFUA_5G00150"
                     /locus_tag="AFUA_5G00150"
                     /protein_end="119"
                     /protein_start="32"
                     /score="53.0"
                     /tool="antismash"
                     /translation="PLWLVHAAAGEALIFINLARLINDQPVYAFKARGFVCGEIYFTSI
                     DECVRTYYEAIKELQPHGPHAILEYSYGGMLAFELAKIWRRK"
     CDS_motif       18032..18100
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_5G00150_0001"
                     /evalue="2.80E-06"
                     /label="NRPS-te1"
                     /locus_tag="AFUA_5G00150"
                     /protein_end="114"
                     /protein_start="91"
                     /score="19.9"
                     /tool="antismash"
                     /translation="QPHGPHAILEYSYGGMLAFELAK"
ORIGIN
        1 aaccctaacc ctaaccctaa ccctaaccct aaccctaacc ctaaccctaa ccctaaccct
       61 aaccctaacc ctaaccctaa ccctaaccct aaccctaacc ctaacacttg aagaagcgcc
      121 ttcaagccag tctattaaca taaatactaa cccacaggga ttcctatgat gttgacagct
      181 gagaggacat atactgaagg gatctatgta tgggcccgaa ggagacacag cagatgtaca
      241 ttagaacctg tattgataca tcagtgatag ttggcatttc ggctgagctg ccgggcgtta
      301 atgaattgtg tgtgtgtgtg tgtgtagtcc acatcagtgc aatggactac tgcatactac
      361 taggtacttg gtatggagcg tgtggaatca tcctgtatca ggcaacccgg cggcgtaggg
      421 acatgctcgg ctcagttgcc aaggtagggt acgaggtccg aacagggccc cgcacggata
      481 aaagacattt tcaatcacct ggtgacctac acagtatgtt ttggcctatt tgaggtattc
      541 gcatgaagtg ttcaggttca tttgtgactg gatgattcag gtctctaaca gtcaaggtat
      601 ttatattagg gtgacttcgg ctctgcattg gcttgggcca agagctacta agcatgcgcc
      661 tctaagccga gtcgcccagg gcaggccgct aatattcccc caataatgag atcaacctgc
      721 agtagtatca aggctagagt gttcaaaaaa aagtccgtgc tacgctagtt cgcatagaag
      781 aacatcgctt acacttggtg ctgccagtag gatttgtgct agttagatta tgatattgcc
      841 catgcttgct gaaccaggat aataaaatac gcagcatgat attgaagtaa agtgtttata
      901 atcagaccgc aagacttgta tgtgctattt ccgatcttgt tgaaagccaa tttgcataca
      961 gagacgtcct agagaatggc taatttctag tagcaggtca atattttctg gccttgctat
     1021 atattgtatc cgttatattt caacacgtgg aacacatggt cgtttagcaa gccccgcagg
     1081 atccttagac gcattttctc ttgacattgt actaaatctg agagatacct ccctctttca
     1141 ttgcccaggg catgtatggg ctccagtgct ctgctagaga agctgaaaag tctccaatat
     1201 gcatgactta ggtgtcccac aaggcacacc aactagatta tggcttgtgc actggactgc
     1261 gccgcaatcc gaaaagtcag ggattaaatt gacgcgatgt aacagtccac actgtattct
     1321 gtatatcgtg ggagtttgat tggttaagca gctatcacga gttgagtata cagggaggct
     1381 cagtattgtt gtcatggccg gccaactgta tccccaaaca acatgctgtg ggatacctac
     1441 atcgtctaca gcagatgtcg ggcgaactag ggccaggatt caactaagta tccgatttat
     1501 ccggtatctg ttgaaacttt ctccgtgcaa gttcctgaga gcaccaaatg tgcctcggac
     1561 atatacttat gcaaatcggg gagtagatag gtcgcgggct ccggctgaga caataaaagc
     1621 acaatacaca tattaagcgc tggaactgtg atagacttgg ttgtaaaacg cctggcgcct
     1681 tgcagcatat agcgcaccat acaaaaggag ataacctccc atttcgatac gaatccccgc
     1741 ccactccgcc cagcagagtg cgaatgcgaa ggctaatgtg acctcgaaag cgaccgagtc
     1801 ccatgtttcg ggctcgagcg ccttccatgg ccatgagcat gtctgtgtcg gcgcccttgc
     1861 ccatacccca gcccagcctc accagcacca acttcacccg cccccctggt cacaaaccca
     1921 gcgaacacca aaacaatcgc cgcgagcaac tcggggcaaa accccaacac aacacgaaca
     1981 gccaaactcc ctgtcgttgg gtttagatcc gcgcgctgtg tgaattccgc gacaagcatg
     2041 tataccactg aaatctcgac gagggcaagg gcgaggaggt tgccggttag gagctgtctc
     2101 gaggcatctt tgtgttagca tataccattc tccgtctcca gaccagacaa tcatatcaac
     2161 gatctatctg gaaaaaggaa ggggatgagc ataccaacca cccctccctc gcggccaagc
     2221 ccgcctgtgc accttggttt ctagcacttt tcctcccccc acccgtccca ttccaaagag
     2281 tccacagccc ccacaaagcg agcacacccc acgaaacctc caacagcacc ataccgacct
     2341 tgatattgga taaatcactg ggcttaggcg tatcgcccaa caacccgcca gcaccaaccc
     2401 cgaccattgc aacccccgtc gcaacgagga catggatgag cgccatgaac gtccattcgg
     2461 ttcgtttgct cggggataaa cagtagattc tcctaaatca caatgagaca catatgagat
     2521 attgcattgg ctcttgctcc tggatgaatg gacaggaaat agggctcggt gcgttgggtc
     2581 agtttttggg taacatacgc ctcatgcaac accccgtcta tcgagagcag cagcggcgag
     2641 agcccgatac tggatattat ccgggagccc gcgttatgcg gatcattgag gcccatggcg
     2701 gcaccggtta cgcgaagaac gcagaaggca aggaggtaga gccaggcgag gaggccatgg
     2761 tggccatggc ggtagaggag gtagagagtt ggaagtgtta ggggggcgta gagggcgagt
     2821 tgcgcgatga ggagtccgga tgtcatcttc actcattcag tgtaggagat gggtgatgtt
     2881 ggtgcagtgc aggtttagga gagatacggg gagatggatt ggggcagagt aaaaggtaga
     2941 caaataatcc attttaggca accagttcta ggccatatag ttaagatgcc agccaagagg
     3001 cccaaggcgc agggccgaga cgctactaaa cgagaccgag aatccttgtc agtcagagcc
     3061 aatcctctgc gacgcctcat gcaagggttc acgaactaaa tccaaacagg caatccagac
     3121 aaaaagcttg aaccaaacaa gaccagcaga tttaagtgcc accacctttc ttcttcttct
     3181 cctggcctcc ttcgatcaaa gaaagatacc tccccaacgc ggtaatagga aaataaactc
     3241 gatacagcgt atacgagatg tagaaatggt tgggaaaccc cgtactcgtg aattcgcgct
     3301 ctgtccacgc cgccgcccca ccgtcaccct gactcaaggt atcatcctgc gtatccacca
     3361 aatgcctcac cccacgctgc acagaccgat cctcgccccc acagactgtc aaaataccca
     3421 taagcgccca tgctgtctgc gagggcgtgg aaggcccaca cccggcccgc cagggctcgc
     3481 ggtacgagag gagggactca ccccatccgc cgtcggagtt ttggacttgc tttagccact
     3541 tcactgcacg agccgccatg gcttggattt ccggcgcgaa cttcgggtcg tgcttgaaat
     3601 actgcagtcc gcacagaaca aggcatgtac catagacata gttgaccgcc caccggccgt
     3661 accaggtgcc cgttgcttcc tgagagcgga tgaggtaggg aattgcgcgg gcgcaggcgg
     3721 tgttgatgat ttggaggagg tgcgcgtcgg ctgccgcatc cccctctcca tcgggatatc
     3781 catatttctc cccattttcg gcattctcgg ccggacgcat cagcaaatcg cgcagcatgc
     3841 ccaaacactc aatcgtccgc cccgtcacat ccggcgtgct cggatcacaa agactttcca
     3901 tatcgctaaa cgggatcttg ttcagaaaca gctggttatt ttcatggtcg aacgctgccc
     3961 acccgccatc ggcattctgc atgcctacaa tccacagcac cgcatcgcgc acgagtctcg
     4021 atcgcgcggt ggccgggtca tgcgtcaaga aggcgagaac ggccgcggcc gtatcatcga
     4081 tatccgggta ccacgtgtta tggtattcga acgcccaccc accgacgggg atgttgggct
     4141 tgtagacgcg ctagtcgccc tcgggcccac ggtgctgatt ctcggccgtc caggccaggg
     4201 cgtcggcgat gcgagggtcc aatttgatgc ccagggaggc gggagtatct tgcaatgcgc
     4261 ggatcatgag taccgtgtcc cagacggggg agatgcagca ttggagacgc ttgccacggt
     4321 tgtcggccca ggtgaagcgt tcgatggctg ctagaccgag ttggataggc tcgtcgtgta
     4381 acttgtaccc ctcgagcaaa agggccttga tacccgcgtg cataggcggg atgatacctg
     4441 cccagtcgcc ggctttctct tggtgctgca ggatccactg gacacagcga cggcgcgcgt
     4501 aacctcttgt agggctgcgg cggagcccgc ccaggtaaga gagggctttg tcgagtatgg
     4561 taaagacaaa agcgacgggg tcggtagggt ctgaggagcc gtaggggagg ggctttgtgg
     4621 ccgggtccag ccagagctca tccaggaacg ggttttgctt gtgtagcccg ttgggaagcg
     4681 ggtagagggg tcggtggtgg gcgattatga ggagcgggac tacgttgctg cgtgcccatg
     4741 aggcaaggcg gtagatgctg atggggaagt gagctgggac aagaataaac tctgcgggca
     4801 gctggggtat ggcagtccaa gggaccaggc cgaactctgc gaagaagatg cgggtgaaca
     4861 tgcgcatctt ggagagcccg ccggcggccc ggatgaaggt tcgcgctcgg tacagctcag
     4921 ggctgtctgt ggacattcct atgattctca gggccaggta tgcctctgcg cttgtggaga
     4981 tgtcgccggg gtagttgggc gcgatgcccc aggagccgtc ggagttttgc tgcaagagca
     5041 gccattggcg gtattggctg ccttcgccgg ggtcgatgtg ttggtagaga acataaagaa
     5101 agaagatgtg ctcgcaggtc acggtcacgt tagactcgag ctcgccgcac cagtggcggt
     5161 tggagaagat ctcccaggcg tagttggttg ctttggtcaa ggctgtcctg gcttgggctt
     5221 cgaggggctt gctggcttct gtagttgcca tggttgccgt agtggccatc gtagtcgtca
     5281 aggttgccat ggtcagtgat accgagcaaa agaagcaggg tgatgagcag agacccttaa
     5341 gtactcgatc aaccgtccgt ctcgttcccc tcagaactag accggtctgg ttgtcatcgc
     5401 ctgcgtaagc gtaccatcat taggggctag cctgtaagtt tggttcttct ccattccagg
     5461 ccagggccta atcattacaa ttcttccaat acgaagggtt acatcaggct aatagtgagg
     5521 gtgctgaatc atcaccacat cagcttacga ctatgcagtg ctatctggac atctattgga
     5581 ggctccctta tcgcacccaa catccgtaaa tgactcacga gaaatggagc agattcagcc
     5641 gaaacccata ccgcagcttg tcggctttcc tctgttacca aaaagaaagt accatacaga
     5701 tatcgaccct aatccggaca ggggagaggg cagaaaggct atataaactt acaaacatcc
     5761 accttcacat ccaccacatc atttacccaa tttaactcct cctgcctaat ttcaaccctg
     5821 tatggaacaa ttgccatcat gtatacagcc cttggcctag ccgtcttcac cgcccttttt
     5881 cactacacca tcgtgctggc aatcaaccac taccggaccc gcgaaatcct atcccagctc
     5941 gtaaaagcgc acaattgctg ccctccaaag actgaacgcc cctgggacat cctgggtctg
     6001 gtcaagatct actcgtcgac caaacacctg ctcaatgaaa ccgcgctgag caacgtctcc
     6061 gccctcttca aatgctacgg cgacacctac gcctcgcgca tcctcaccca gcgggtgtac
     6121 ttcacctgcg acccacgaaa cattaggcat gtcctaatca ataggttcag cgactttgac
     6181 gcgtcggatg tacgcgccca cctcttcgcc cccattacgc cgcacggcat ctttgctgtg
     6241 gacggggcgg agtggaaaga ggccagaagt ttgtatgcgg acatcttctc ggcaaccagg
     6301 aaaatctttg atcttcagtt gcaggaggat ggcttccagg gcttgattaa gcagatcccg
     6361 cggggccagg ccatggacct ggcgccgctg tttctgaagc tggtactgga tgtgaacagt
     6421 gcgtttgcga tgggaactgg gctggacacg ctcaaacagg atcagtcact ggaaaagaaa
     6481 gaagtggccg aagcgctaat gtacgccaag aagattatgg cgcgggacgg gtttctgggc
     6541 ccgttgcatt atctcctaag tcgcaaggac ttttatgcgg cttgtgagac tgtcaaggcg
     6601 tatgtggaga aggttgtgag gaaggaaatg acggcgaggg agtatcagaa gcagtccaat
     6661 gcagccacag tggacgacga gcgtcagaag cgaacgcaga gtctcctgtc acggatcctg
     6721 gataatacca acgacgtcca tgctgtccgt gacgcggttg tcacaatact gattgcgggc
     6781 acagactccg tggctagtat gttgtccacc acgttctatc tcctcgcacg ccatgagcgc
     6841 gtgtatgcaa agctgcgcca ggaaatcttg gacacgatcg gcaccgagcc cccgacatac
     6901 gacaacatca ggaaggccac ttatctccgc tacgttttca acgaaggtgg gtcagcgtac
     6961 ttacctggaa aatacaccag cttgcaaact gactgaacct ctagcaatgc gcgtctatcc
     7021 gccggtcccc ttcaacgccc gcaccgccaa ccgggacacc tacctgccag cgggtggggg
     7081 tccagacggg caatcgggtg tgctcatccg caagggccag cgagtcatct tcgcctcgtg
     7141 gggcagccac cggagtacgc gctcatttgg ggctgatgcg ctcgagttcc ggcccgagag
     7201 atgggagggg ctgaagagtg agtcgttggg ttacatcccc tttagcgcgg gcccgagggt
     7261 gtgtctaggc cgtgagtgat aatcccttcc atatatgcct ttcttgttcg tgacgacgat
     7321 gctgatagca gtggcgaggg tggtagaaca atacgcgctg ctcgaggcgt cgtacgcgac
     7381 gatccggatt attcagacct ttgaacggct tgaaaacaga gatgtgcgcc cgtggacgga
     7441 gaagattggc ttgaacttgt cgaacaagaa tggggtgctt gtggaattgg tgcactgaag
     7501 tcgtggaata caggcatatg cgtgtctggc gagactgcag ggggccgcta gacgtagtta
     7561 ggtagccaat cagggagcac tcacatgaag atggcttgaa gactacttaa tatgattggt
     7621 aacacccttg ttcaagcctt gcccagtctg ctcaagcttg cccaagcctt gacaggggcc
     7681 agaatcctcc gccaaaatct caccggcgcc aacacggaca acccctctct tatattattt
     7741 tggtccctca atatgtgatt atgccgcatc atcacgacaa ggatggctag atgagacgcc
     7801 agagctggga attggcccca agaccgagac cgaaaccgag accgagtatc cctgtcgcgc
     7861 tgtaagtatg gcatcataga caagagctgg tctaatttcg atagagacaa tcgggaagca
     7921 gacatatctc caacactcct gtagggctat gttgtatcgt agaatgtagt ggatatcaac
     7981 tctcttgcgt ccaccctggg tgaattcgaa atcacaattg cttctaaacc acactgcaga
     8041 caaaatggcc atcccaacaa aagaaagggg tagccgcctc actgacgccg atattctatc
     8101 cgatctccaa atgtacaagc ccgtcaccga ttcagacacc cgcaatgttt gggccttctg
     8161 ggacaaaggc ttatccaaca gccctgcatg gaaccagcgg aatgtcatta gttgggtccg
     8221 acggctcagt cccaaatgga cagtccgagt cttagacctc gtcgagggct cacccaacca
     8281 tgtgtcccag tttattccac gagaaatgct cacagatgtc ttctggaatc gaacaatgac
     8341 gggtcctcat gtaggacagc atagctctga ccttatccgc ctaccgctac tctacctcta
     8401 tggcggagtg tggctggacg tcgggatgct tctgttccgg tcgctggacg ccctgtgctg
     8461 gaatgccttg gaagatcccg agactccgta cgaggtggcg gcgttcaagg tctccatggg
     8521 ccccgagtta tccttcctgt tcaacgggtt cattgcggcg cggcggggaa gtgtctgcat
     8581 caagtattgg catgagattt tccgcacgct gtgggatggc gcaacgagct gtgcggggat
     8641 gcattcacac ccgctgctgg cgcatctgcc ggtctacgaa ccgccctcgt tgaacggaaa
     8701 gcgcccaccg ttcatgtatg cgcagttcgc agattacctc gcccaggtct tttgtctgga
     8761 acggctgagg cacctggttg actccaaaac gggatgggac ggaccaaagt tcttcgaaga
     8821 gaaggttttg ctctttgatt gtgtgacaga agcgtactgg gcgcagagat tgacggactg
     8881 gaatgggagg aagcagtatg agttgttgga cttgcaacgc ggcgaggacg gtttggacaa
     8941 tgcgcgagtg aaggaggctg aggcacttgt ccaaggtgtg ctgagcatgt catcgacaat
     9001 gaagctatca catggccttg ttactgcagg ccgagagtac ttagctgata tatgggacag
     9061 tccgaagaac cacgacgcgg atatcagacc agggacgttt gcagcgtatt tgcgagaggc
     9121 cagcgagacg tttgagcaga caaaagagct ggtgccgctt aggatgcctg tgatcgagaa
     9181 ggcgctgctt cgggcgggag tcacagaggt ggttagatag cgagttgtgt ttgatgtgtg
     9241 ccatgagata tagttatttc cactggccag gacattagac gttcccaatg ggcaggaagg
     9301 ctcggttgaa gagtcatgat gtatttgtgt gcagcgtctc cgatccacca tatgtcacgt
     9361 aatggtgcgg acaaggctag aaagtaagct agaaccacca aagcgcgagg tctcctcttc
     9421 tcgagtaagt caataaaccc agctgtcacg aacaaaggga agaccatgag ccggcgacag
     9481 ctgatttgcg gatgttcctt tgcttccatg gccagccagg tggcgttgat atgcgcgacg
     9541 gcccctcgat atgcttctag cgccgtctcg tcatcctcgt cgtcgggcac agtcggaagc
     9601 aggaaggaaa atgatccagc atcagaactc gtccgcaagg gcataggaaa ggtatcaata
     9661 atacaccaga tattcggggg atgagtatta tgtctcacaa tctccatggc cgcgtcaaag
     9721 acggctaccg acccgcgcac tagacgcatc cattcactta cctgttcgta agaaaccaca
     9781 tgacgacttt gtaaagtagc aaatacatcg atctgtaaca ggatgctcgt aaagcacacc
     9841 gcatccgcgg tctgcgtagt tatgccgccg atacagagtc gatgttcgcg caaagcctgc
     9901 tcgaggaaat tgcagtggat gtccggcaag ccagcttcgt ctgggttgac tttggacaga
     9961 tgcagggcag cgattgcgaa gacggcgtgc aggagcggtt tgtaactgaa tgcgagtcgg
    10021 ggcacgtcga tcgaccaaca gtctttgata cgcttcaggt gggcgccggg catagtagcg
    10081 ctggtgaata gagtaaagtg atgcagcaag cgcagctcca tatgtgcgtc attactggga
    10141 tccgatggac tgggctcgag tgggcgagat tggatcccgg ttgagggggg gatcgctccc
    10201 tcctcagcgg gcctgtcata aacacagggg atcccatgac gatggcagtc gcgacacaca
    10261 ggtcgcgatt catcacacta catcagtcag gacagatttt gtagcaatgg atccaccgta
    10321 cctttactcg tcgggcgcga catcgctgac atccggtcct ggacttacgg tgggcgagac
    10381 gggggccttt gcgcttcttg cggttgtacg agtccctttc gctttggttg tggcctcgtg
    10441 gcgaagagga cgagttactg tctgggatgg ccgaggtcat cttgcttcgg tccaacatgt
    10501 catggcgatg gagttccagc gcagcgatga catatcctgg ggtctttcgg attcggtgaa
    10561 gaggagcgaa gccttcctca gtttgtctag cgggaaccac gatcgccgaa tggttgacct
    10621 gtgggtactt gcctccaaaa atggaaagac gggccagcag aaggtactgg aagtagtagg
    10681 taagttacct gaatattaaa ctcctcttaa agtaggcaat aataaatagt agcacgtccc
    10741 acccagatag gtgtaggccg ccagttattg agtgtaacaa aagttcctga tggacggggg
    10801 ccgccctcac tagcaactcc cggtcttaat gtaatcaatc caccgccgag ctgaccaacc
    10861 acccccctgc gagccgatca cccctcgtct gatttctacg cgtttgaaca tttgaagcca
    10921 tccaaatcaa ctaaaatgat atacttttca ttagatctag ctagtgcagt gtgtagcgca
    10981 gctagatcca gtatgtctaa taatgaagta attagaaccc cttagtggcg tgtatttaga
    11041 aggttctaag gtaaacgctt ggaaccacta actcactgac ccctaacgta attcccagac
    11101 gagccggaca ctccatcaca tttcaatgtt tttacacctt cgatgctatc aaaacagcta
    11161 ccatgccaca aaaatcatgt caaacctctc aaaatctagt atatcaagag gggaggatct
    11221 tattagcaat atcatctttg aaaaagcagg aaattcaaag tatcaccatg ctgcagagat
    11281 attcaacgtg cctaagtcaa ccctctacaa tgacttcatg gatgccaata ttaattgaag
    11341 aaatgcgcaa ataactgtcg gcgatctcct acacaggaag aattattagt agaatggatg
    11401 ctatctaggt atcagtgtgg agcgcccctt tgcgccatct tatatataag aaatagccaa
    11461 tatccttctc caggcagatg atccctctgg attcaaacct agtagtaaga acgggcttga
    11521 atcttgttgg cttgaaggtg aattgaggac tgaattaagc cttaagttga gagcagatat
    11581 gagcgcaggg cttgcagtag ttgaagctga atttaacgcc gagctaagag ctgatataag
    11641 cgctggattc gacgctggat tcgacgcatc tgactctgag accggctccg atactggctc
    11701 tgatactggc tctgacagag tatctagtgc agggtttgat gtattaagca cctcagacaa
    11761 atattcttgg acttggttgc gtcgcagaat tctctctatt tcttcgtctt cctcctcaag
    11821 aagcatctcc tgtgtgattg tggttggtaa ctctgcccga atctgccgtt tattgatctg
    11881 tatatagagt agcttctcaa cacggtctgt ttcaagtcga tttcgggtct ttgtatgctg
    11941 tagattcatc tgtgagaatg ccctctctgc tgctgcagag ttagcaacag tattgcaaag
    12001 ccgacgtgca aagggagcaa ggatgggggc aaattctgcc tatttaagca cacatattag
    12061 caagtccgtt taaattaggg cactgactta ctgcttcaag ccaaaagagt gacggagact
    12121 tggcttccca acaagcagaa ttataggaag caccagtttt ttgtcggaat gcaaggaatt
    12181 catgccacgc agaggagctt ctgtcttcat tttgaagtgg tcgtagagca ccttctatac
    12241 ggcgtcgtga actctcatcc agcttgccag ggactcttgc tggatcaaga tgatatgcca
    12301 cccagtggag tggttctagt tgacgtagta ttcgactctg ccaaccagta ccctccaggt
    12361 aggaataaaa atcatcttta aaggatgtct ggctagacag cgtctgtaga ctttcatgaa
    12421 gagctaacca ccgttctgtc acctccatca ttgaagaatt ctgggcttca gattccttct
    12481 gagcaatatg caaaggctta agaatcttta ttaactcctt taactcccac caaatccatg
    12541 agacttggca gtcttgacta cttctcttgc cttgatagca gaagatgtag gtgtaataag
    12601 agcccattca cagattgcgt cctggctctc aaagagagaa gtaagcatac tatattgagt
    12661 cccccatcgg gtaataacgg aggcaatcaa ggcctttcta tgaccccatt tctcattctg
    12721 cttggcttgc attctcgcat attcaagagg agattgatga aagaagacca caattttaag
    12781 agctgatttg aagacggctt ttacctttgg gatcttcgaa gaatttggat caagaatatc
    12841 cttcataatc agttgcagac cgtgggagtc acagggaacc ataaaggcat gtttaagttc
    12901 tggtttctct gacaagattc cccatactgc tttcatcaca ccgcaagtat ctgttgatat
    12961 cgagttgatc ctcttccagt caacgtcttt gtccaattcg gaaaggagag catgaagcct
    13021 cgtgagtatc cagtcactaa ttgtaggagc atcaagagtc tgatctttca tatcattcaa
    13081 ataaagaaac catgatcttg tgggcgttgt aaccgtcatt acaatgaccc gttgggatcg
    13141 tatatttgtg gtctcatcca cggtaatatt taagaattga cttctccgta gctccttcag
    13201 aacctcccta tgtaacccat tataggactc ctttaggaga tcatcagcaa ttcggtggcg
    13261 ggagggtatt tggtataagg gatttaacgc atagataagg tctcgtatct cttgctgctc
    13321 aaagagactg aagggtctcg ctcccgtaaa acacacttgg gctagtaaat gatcaatgct
    13381 cctgcctgac ccagagatag ggaagcttag cgatttttgt ttctttccgc tcccgatcat
    13441 aggatccatt aatacttgtg ctttactaca tttctttaca tgctcgctct gacgagtggt
    13501 gtttttggcg cggactttag agcaccccag gcattttgct tgtgggacct agagatatca
    13561 ataatttgca gagaataggg tgttgaatgg taccttttta ttgccctgta tgatttcaaa
    13621 gcacttttga agctcaatct cagtatagtg gatcgtttca gcagaatttt cagccatgtt
    13681 gacagtggga ttgctacttc tacagaatct atgggcgaag atatatattt gtgactctgg
    13741 ttgctaccag ttacttcagg catgctggat aagataatga ggctggcaga atttgacaaa
    13801 gttagtttca attggttgcg gaatttcacc gcttagtatg accaagcaac cgaccctccc
    13861 atgaaatgta attgaaatcg ggaaaaagga tgaaatttca agatttcgta atgagcttgt
    13921 ctgtattgtc attacaccaa cacttccaag ttccaacttg gaaggttcca tcccaaagtt
    13981 ccaagtccca gccgcccatg gatcgcccgt acgggatcca tacgtatgtc cgtatgtcat
    14041 taattcggat tacagttata taacattgtc gtaaaataca cggaagatag atattccatg
    14101 gacttgctat ttacggttta gctccgtttc ggatgaggtt tcaggaaaga agttagaagt
    14161 ataaacattt gcaccggtat tgcatccagc tgtaccactt gacgatggcg ggcctttcat
    14221 cagctgcgct atgtgatcag cttctcattc ttgtccgcgg attcggcggt gtctatttca
    14281 tttcgttgac cacaagcgtt ctttgcaact atctccgtct cccggtcctt caagcgcaga
    14341 gcgagatacc gagtgccttt gcccttgtac tattctttat gacggcagcg gcattctgtg
    14401 gcttgagctt gttcaaccaa ttagtgcagc agtcttcaag cctagagcaa acagcgacta
    14461 tactcctgat agctacctca acggcctcct tcgtctactt cgagtatacc gaccgatggg
    14521 cccggggcct ttacatgttc gccatatttg ttttgggtac ttggttcctt ctgtgcctct
    14581 ggcaaaagaa aacaaccttc ctcgcagtat gtctgtctta tggatcgcta tgtttaatcc
    14641 cggctataca tgcaatcatg agtccgcgcc cgaatcaacc gcgaatcgca gatgattttg
    14701 tgaaatactc ggcactgaat gctataggag gcctggccta ttgccttcag attcccaaaa
    14761 gaatctctgg ccttaaatcg agctcggcac ttagcatgaa tgtctgcgtc gtcgtggcgg
    14821 cgataatctt ctctgggaag ctgttagcgg cccatggata acaggcccac ttagttgggt
    14881 ctgccgagtg tgatgtacca aatgagtgcg caattagaac aggtcgcttt tgtggcaggg
    14941 ttggttaact gagcgtggag gagcctagat tagaattaaa ttatgtggtt catctgcaaa
    15001 gcagtcagct tcctcagtgt cgtcaatggt ttcacagtcg ttctggaagt cgcattagat
    15061 gaagttgagt ctttgtgcct gccggacaat ggttcggaag tgggcagaat ccttctcccg
    15121 aatctcgact ttggtctcct ccagtgcata aaactacgag cccattgtca cgacgccatt
    15181 cctgattaga tgcacttata tattatatat tatctctatt tggatgatta aatgtcgatt
    15241 ccttctgatt tacgtcaaga tatagaattt tgtcccgtga aaatttagct ccttgaggtt
    15301 cccctctaat ttcgtcgatt gcatcttctt ctggcccgga cagacccttg ttaatgaagt
    15361 gaggaagatc agatcacatc tttgtgtatg agagaaccat tctcttccgc ctgtcagaac
    15421 aattacacgg caagtctgga gaatgcgaag ccttgcatgc cacgtatgca ttcaaatttc
    15481 tacattatcc gcagtagtac gcttgccatg tcttcgctgt cgccttcagg acagcccacc
    15541 ggaacttggt cccgaacagt ttctgctgtc gtttcctcag gctactcata caccagcagc
    15601 gcctagagac gaagtctaca tgtaagtctg atccaaagag attctctcaa attagataga
    15661 tcgcaagata agtcccagga cgataacgca gtaattatac cctagccgac ttcccatgct
    15721 ctacaggcac agtgcctaga ccagccactt aagcagagag cgccttgtga gcgctatcaa
    15781 aggcagcatt gacttcagca accttgggct cagtgctgcg gtacctctca gcaggcacct
    15841 tctcctgcat agttgtcttg aatttctcct tctcactctt gagatcatcc atcatagccc
    15901 tcgccacgaa ggccactccc gcatctttga aagccggcgc ctgggtcggg tcagcactac
    15961 gggccattaa atagggaggg gaatgacata ccttctgctc tgcagcatta agcgctccca
    16021 caatttcggg ctgcaattgc tgatatgctg ccagaacttc atcttggtcc tcatcgccaa
    16081 atgcatcaga ctgctcaatg gtcctgcgtg tgtcggcagt ggaactcttc acgccttgca
    16141 ttttgctggc gatggggatg acgcctaaaa ggccaccgtc ccatccctcg atgctctcgc
    16201 gagccttaga gacgcgtttt tgcagagtat tcataccctc gatagcctgc ttggtgttta
    16261 cttcacccag ggcggatgtc gcgagggcga cgagcagcgc tactggggtc acgcgggaga
    16321 agagcattgt gtcttaggaa agaatgggat tgggttgaaa taaaatcaag agtgtactgt
    16381 gattggggat gtcttaaaag tttgtttcat gtcatgactt tatagccggg gcagcgtcgc
    16441 caaggtccat tcctatatat cacactggcc caagacaggg aggggcaaat accgttgacc
    16501 atacccggaa tgtgaggggc cgccatcgca gcaaattctc cgttacgtgg tttgaagtat
    16561 gaaagacagc aggagaaaca ggggagcact gttcgccatt aaatatcctg cagttgaggc
    16621 taaatcccca tgtatgcagt gtaactctga tactagatta tgaggctata tcctgaatat
    16681 cccttcttgt atacagtata aacccgacct acctgccaca ttcaagcatc catgcgccgt
    16741 agatagaatg caaagggcga atttggcatt ctccgggaaa taaaggggct tcctgatact
    16801 ggcaagacgt atgacttaat gcttgatgat ggcaggtttg acaatataca tatttttgac
    16861 aacagcggat gttgccagct caaggaagga cccgtccttg ctctgtggcc gcagcgtcaa
    16921 tctccaggga aaacatccaa gattcatctt atagccgctc tgtcattata cacccttctt
    16981 actctggctg cacccgtcac ggtacaattc tgattgagga tctcgaatgt ctcttcccac
    17041 gtaacggttt gtgtctggtc aggccgaaca agattgaagg cgaggcagag gttttcactg
    17101 aacagagaaa tccgcagcat ggaggagcag acaaagcgaa ctgcaatgaa ttggtgtcgg
    17161 gcatgtggag taacaggata gctgcaaatg cgatgacagt tggctatcag acgattagta
    17221 gcatgctgct gtttatgggc cccagtgacg ctctggcgca tgacgaatcc aggcggatat
    17281 actggagaca taattgtgcg gcttagggcg tccagtgtac gcaaaggcat agctattact
    17341 ccaatgatgc aaaagccagg tatgaaacaa tgaccgccat atcacaccga atcatgatga
    17401 tcacaaacgt gcgactgtac atacttcccc tgcatgccac ggaacgaacg tcgttggcgg
    17461 agctcccccg ttctaccttg cagcgcggag ttgcaagtgg ccaattatat ggaggagact
    17521 gaaagtgaca acctgatctg aacgtactcg caacaaacta tattcaaacc gcctcagtca
    17581 ccaattgagc aagctatttg tagaggagct ggcggaactc ctctgcctat ctcgagatga
    17641 tattgagata gataccgacc ttctcgaatt gggcctgacg tcagtgaacc tcattcaact
    17701 tcactatcga ttgcagagga gactgttgcc tgatgagatt attcctcttc ctactatcat
    17761 ggcgtaccac accatacgag gtttagctga ggcatgccag cagcgtcacc agtatatccc
    17821 ggcagtggcc ctccagccca agggtggaaa gtctcctcta tggcttgtgc atgccgcggc
    17881 gggcgaagca cttatattta tcaaccttgc caggcttatt aatgatcaac ccgtctatgc
    17941 tttcaaggct cgcggattcg tatgtggcga gatatacttc acaagtattg atgaatgcgt
    18001 ccgcacttat tatgaggcaa taaaggagct tcaaccgcac ggcccacacg ctatacttga
    18061 atactcctat ggtgggatgc tggcgtttga gcttgccaag atttggagaa ggaagaagat
    18121 caggttcaat ccttggctag cctgaaccgt cctccatatg taagcgcacg tctgcaggag
    18181 gtcaagtgga ccgattgtct ggtgaacatt tcttacttct tgggccttct gtctcgagcc
    18241 tcattccgcg acctccttca gcagctatac cacctaccta agaaagaggc aaccgcctgc
    18301 ttgatcaagg tagctgaccc agctcgcctc gtagctttag cgctcgataa tgacaagcca
    18361 gagcaatgga tcgacgtcgc ccctagtccg caagaggtag gcaggaacta cacgccacaa
    18421 ggatcagtgg cacatatgga cgttttccac tgcgaccctc tcgagttcct caatgttaca
    18481 cctcaagagt ggcaacaacg tctgtcttct tggagagatt ctcaaggcag aggatcaact
    18541 tctttcacgt gccaggcgag cacttcactg ttctgggacc ggcaaacgtc taaacattcc
    18601 tcaaccgatt ga
//
